The Parish Church of S. Maria is located in the small hamlet of Guazzano, a few hundred meters from the town. Dating back to the 16th century, it already existed in 1530, when S. Maria "de Canzano" (or "Cazanum") contributed to the professorship (tribute due to the bishop) of the land of Campli, paying 3 “soldi” and wheat annually.
The patronage was mixed: in 1539, in fact, it belonged to the provost of the disappeared church of S. Margherita di Campli, to the Tosti and to various Camplesian families. The historian Nicola Palma writes that Garrufo was a dependency of this parish.
The interior, recently restored, has a nave with an apse and a gable roof supported by a trussed vault, a walled plaque dated 1474 and two stone stoups. Behind the altar there are three niches, two with statues of saints, in the central a clay statue of a Madonna without a Child.
It is the work of the Nocellese school; the hands are made of wood and furniture. On two tiles of the apse cover the date 1881 of the restoration; on the right side the bell tower with the date 1885 on a stone slab under the belfry; built in part with irregular square stones bound with little mortar.
On the facade there is a portal with a lowered round arch, surmounted by a small oculus. On the left, on a square block, a Roman dedicatory epigraph, perhaps coming from a republican domus.